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NICEATM requests nominations/data

Executive Summary

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods requests nominations of experts to help evaluate the usefulness and limitations of Xenobiotic Detection Systems' stably-transfected estrogen receptor transcriptional activation assay (LUMI-CELL ER) and Certichem's cell proliferation assay (MCF-7). Center also asks for data generated through use of the in vitro tests - both used to determine whether chemicals interact with estrogen receptors - as well as relevant data for 78 reference substances recommended by NICEATM's Interagency Coordinating Committee on the Validation of Alternative Methods for use in validating such technologies. Possible candidates for international independent scientific review panel include experts in biostatistics, cellular biology, endocrinology, molecular genetics, regulatory toxicology, reproductive toxicology and test method validation. ICCVAM's efforts have facilitated the approval or endorsement of 31 alternative methods by federal regulatory bodies since 1997, significantly reducing animal use, the center notes
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